Post-doc / Engineer, in vitro and in vivo preclinical tests for electrophysiology recording and stimulation via an innovative medical device.

BrainTech Lab is a translational technological research unit dedicated to the development of innovative neurotechnologies for brain diseases. The Lab addresses biomedical needs related to brain tumors, neurodegenerative diseases, or disabilities.

This post-doc mission will contribute to the validation of the proof-of concept for a new medical device (MD) ‘Neuro Snooper’ in preclinical models (animal/in vitro), a required step before initiating a clinical trial (Technology Readiness Level from 2/3 to 4). Already existing MDs with electrode wires are either very stiff or with a milli-metric dimension. The ERC work has led to a first generic, miniaturized prototype implant with moderate invasiveness and which design was validated in connection with neurosurgeons. It is in particular suitable for the glioblastoma (GBM) application. In a long-term perspective, it will help to characterize brain signals and hyperexcitability in several brain diseases.

Missions

- Perform cell characterization around the future medical device: impedance measurement, electrophysiology recording/ stimulation (in vivo/in vitro), signal analysis, immuno-cyto/histo-chemistry, microscopy

- Keep appropriate experimental records and documentation and present the results analysis to the Principal Investigator

- Keep a notebook for the characterization of each medical device

- Participate to animal experimentation and to in vitro cell culture

- Participate to the micro-nanofabrication in clean-room

- Participate to the redaction of publications

Scientific and technical competences

- Electrophysiology (in vitro cells/tissues and/or in vivo)

- Signal analysis (spike sorting, local field potentials, correlations and fourrier analysis)

- Immune-cyto/histo-chemistry

- Cell culture is a plus (cell line, primary cells)

- Habilitation for animal experimentation (not mandatory but it is a plus)

- Neuroscience, electrochemistry or electronics for neuro-recording

Soft skills

- Communication skills for a successful interaction with the research team and in particular with the medical/ preclinical staff.

- Ability to learn new techniques, in particular cell culture/ micro-fabrication (clean-room work: optical lithography, material etching and deposition, etc).

- Meticulous work for the reproducibility of biological and technological process

- High motivation for medical research

Remuneration

The salary will be adjusted based on qualifications and experience.

Contact

Candidate should send a CV and a motivation letter to gaelle.offranc-piret@inserm.fr